Hospital Findr / Find Doctors / New Jersey / Dr. Kathleen Ann Haines

Dr. Kathleen Ann Haines, MD

Immunology, Pediatric Rheumatology, Rheumatology
50 years of experience
Hackensack University Medical Center 30 Prospect Ave, Hackensack, NJ 07601
(551) 996-5430

Overview
Location
Expertise
Insurance

Brief Intro

A critical host defense mechanism in response to bacterial infection or tissue injury is an influx of polymorphonuclear neutrophilic leukocytes, or neutrophils, to the affected area. Once at the inflamed site, the neutrophils ingest, or phagocytose, bacteria or damaged tissue and release toxic oxygen metabolites (O2H2O2) and proteolytic enzymes to digest the phagocytosed material. Activation of these neutrophils is initiated by local production of compounds known as chemoattractants, either by the body or the invading bacteria. Similarly, bacteria that have been "tagged" by antibodies binding to their surface also provoke activation of neutrophils. However, in autoimmune diseases in which the body "tags" its own tissue with antibodies, this response becomes pathologic as the neutrophils trigger inappropriate inflammation. We study the intracellular signals produced by neutrophils after activation by chemoattractants, aggregated immune complexes, and antibody-coated particles. We have used a unique protein produced by Neisseria gonorrhoea (Por) as a probe to dissect which signals are requried for the idscrete responses of chemotaxis, O2 generation, and lysosomal enzyme release. Pretreatment of neutrophils with Por inhibits the release of granule enzymes triggered by chemoattractants and, in parallel, inhibits the production of the diglyceride class of second messengers. Interestingly, Por does not inhibit neutrophil function triggered by immune complexes thus indicating that chemoattractants and immune complexes activate different signaling pahtways. We continue to examine the relationship of other signals such as protein kinases, phosphatases, and lipid products to neutrophil function in bacterial infection and pathologic inflammation to help us understand and control this important aspect of both health and disease.

Education Background

MEDICAL SCHOOL

Albert Einstein College Of Medicine Of Yeshiva University - 1975

Languages Spoken

English
Spanish

Location & Hours

Hackensack University Medical Center
30 Prospect Ave, Hackensack, NJ 07601

Specialties Treated

Immunology
Rheumatology
Allergy & Immunology
Pediatric Rheumatology

Conditions Addressed

Bronchial Asthma
Psoriasis

Insurance Accepted

* Insurance information may change frequently. Please verify directly with the provider (doctor/clinic).

UnitedHealthcare
Aetna
Cigna
Horizon Blue Cross Blue Shield of New Jersey
AmeriGroup
Aetna Better Health
UPMC Health Plan

Cancer 31
Cardiology, Heart & Vascular Surgery 14
Orthopedics 41
Neurology & Neurosurgery 30
Gastroenterology & GI Surgery 43
Pulmonology & Lung Surgery 51
Diabetes & Endocrinology 32
Children's Hospital 13
Urology 51
Psychiatry 35
Geriatrics 49
Rehabilitation 14
Obsterics & Gynecology 10
Ear, Nose & Throat 5
Long Term Care 9
Maternity Care (Uncomplicated Pregnancy) 32